Contribution of ethnicity, area level deprivation and air pollution to paediatric intensive care unit admissions in the United Kingdom 2008-2021
BACKGROUND: There is emerging evidence on the impact of social and environmental determinants of health on paediatric intensive care unit (PICU) admissions and outcomes. We analysed UK paediatric intensive care data to explore disparities in the incidence of admission according to a child’s ethnicity and the degree of deprivation and pollution in the child’s residential […]
Transport of critically ill children to paediatric intensive care units in the UK and Ireland: 2013-2022
CONCLUSIONS: We have demonstrated an increased use of specialist paediatric transport services and changes in the PICU population over time. Routine data collection from the transport services provide a means to measure improvements and changes over time in the service provided to critically ill children and young people who need transport to the PICU. Arch […]
From Storage to Survivorship: A Scoping Review of Young Adult Cancer Survivors’ Experiences and Preferences in Reproductive Survivorship Care After Fertility Tissue Preservation
Despite improved survival rates for childhood cancer, around 60% of survivors suffer lifelong health problems due to their treatment, including fertility issues which account for one third of these problems. Ovarian or testicular tissue cryopreservation can be offered to patients whose cancer treatment puts them at high risk of subsequent subfertility, but it presents unique […]
Use of selective gut decontamination in critically ill children: PICnIC a pilot RCT and mixed-methods study
CONCLUSIONS: PICnIC’s findings indicate that a definitive cluster-randomised controlled trial in selective decontamination of the digestive tract in paediatric intensive care units is feasible with the inclusion modifications, which would need to be included in a definitive cluster-randomised controlled trial to ensure that the efficiency of trial processes is maximised. Health Technol Assess. 2024 Feb;28(8):1-84. […]
The Impact of Specialist Care on Teenage and Young Adult Patient-Reported Outcomes in England: A BRIGHTLIGHT Study
Purpose: In England, health care policy promotes specialized age-appropriate cancer services for teenagers and young adults (TYA), for those aged 13-24 years at diagnosis. Specialist Principal Treatment Centers (PTCs) provide enhanced age-specific care for TYA, although many still receive all or some of their care in adult or children’s cancer services. Our aim was to […]
Early educational attainment in children with major congenital anomaly in the UK
CONCLUSIONS: These novel results demonstrate that poor educational attainment extends to children with urinary, limb and gastrointestinal CAs. We demonstrate the need for collaboration between health and education services to assess and support children with major CA, so every CA survivor can maximise their potential. Arch Dis Child. 2024 Mar 19;109(4):326-333. doi: 10.1136/archdischild-2023-326471. ABSTRACT OBJECTIVE: […]
Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCT
CONCLUSIONS: NIDUS works effectively, delivering appropriate blood clearances and accurate, controllable fluid removal (ultrafiltration), indicating that it has an important place alongside other dialysis modalities for infant renal replacement therapy. Southampton (UK): National Institute for Health and Care Research; 2024 Jan. ABSTRACT BACKGROUND: Critically unwell babies in intensive care units may develop acute renal failure. […]
Selective digestive tract decontamination to prevent healthcare associated infections in critically ill children: the PICNIC multicentre randomised pilot clinical trial
Healthcare-associated infections (HCAIs) are a major cause of morbidity and mortality in critically ill children. Data from adult studies suggest Selective Decontamination of the Digestive tract (SDD) may reduce the incidence of HCAIs and improve survival. There are no data from randomised clinical trials in the paediatric setting. An open label, parallel group pilot cRCT […]
Implementing early rehabilitation and mobilisation for children in UK paediatric intensive care units: the PERMIT feasibility study
CONCLUSIONS: A randomised controlled trial is recommended to assess the effectiveness of the manualised early rehabilitation and mobilisation intervention. Health Technol Assess. 2023 Nov;27(27):1-155. doi: 10.3310/HYRW5688. ABSTRACT BACKGROUND: Early rehabilitation and mobilisation encompass patient-tailored interventions, delivered within intensive care, but there are few studies in children and young people within paediatric intensive care units. OBJECTIVES: […]