Early educational attainment in children with major congenital anomaly in the UK
CONCLUSIONS: These novel results demonstrate that poor educational attainment extends to children with urinary, limb and gastrointestinal CAs. We demonstrate the need for collaboration between health and education services to assess and support children with major CA, so every CA survivor can maximise their potential. Arch Dis Child. 2024 Mar 19;109(4):326-333. doi: 10.1136/archdischild-2023-326471. ABSTRACT OBJECTIVE: […]
Evaluation of efficacy, outcomes and safety of infant haemodialysis and ultrafiltration in clinical use: I-KID a stepped wedge cluster RCT
CONCLUSIONS: NIDUS works effectively, delivering appropriate blood clearances and accurate, controllable fluid removal (ultrafiltration), indicating that it has an important place alongside other dialysis modalities for infant renal replacement therapy. Southampton (UK): National Institute for Health and Care Research; 2024 Jan. ABSTRACT BACKGROUND: Critically unwell babies in intensive care units may develop acute renal failure. […]
Selective digestive tract decontamination to prevent healthcare associated infections in critically ill children: the PICNIC multicentre randomised pilot clinical trial
Healthcare-associated infections (HCAIs) are a major cause of morbidity and mortality in critically ill children. Data from adult studies suggest Selective Decontamination of the Digestive tract (SDD) may reduce the incidence of HCAIs and improve survival. There are no data from randomised clinical trials in the paediatric setting. An open label, parallel group pilot cRCT […]
Implementing early rehabilitation and mobilisation for children in UK paediatric intensive care units: the PERMIT feasibility study
CONCLUSIONS: A randomised controlled trial is recommended to assess the effectiveness of the manualised early rehabilitation and mobilisation intervention. Health Technol Assess. 2023 Nov;27(27):1-155. doi: 10.3310/HYRW5688. ABSTRACT BACKGROUND: Early rehabilitation and mobilisation encompass patient-tailored interventions, delivered within intensive care, but there are few studies in children and young people within paediatric intensive care units. OBJECTIVES: […]
Educational attainment of children with congenital heart disease in the United Kingdom
CONCLUSION: Children with CHD have lower educational attainment compared with their peers. Deficits are evident from school entry and increase throughout primary school. Eur Heart J Qual Care Clin Outcomes. 2024 Aug 8;10(5):456-466. doi: 10.1093/ehjqcco/qcad068. ABSTRACT BACKGROUND: Educational attainment in children with congenital heart disease (CHD) within the UK has not been reported, despite the […]
Is there a sex difference in mortality rates in paediatric intensive care units?: a systematic review
INTRODUCTION: Mortality rates in infancy and childhood are lower in females than males. However, for children admitted to Paediatric Intensive Care Units (PICU), mortality has been reported to be lower in males, although males have higher admission rates. This female mortality excess for the subgroup of children admitted in intensive care is not well understood. […]
Delivered relative dose intensity in adolescent and young adult germ cell tumours in England: Assessment of data quality and consistency from clinical trials compared to national cancer registration data
Adolescent and young adults (AYA) with germ cell tumours (GCT) have poorer survival rates than children and many older adults with the same cancers. There are several likely contributing factors to this, including the treatment received. The prognostic benefit of intended dose intensity is well documented in GCT from trials comparing regimens. However, evidence specific […]
Patient and public involvement to inform priorities and practice for research using existing healthcare data for children’s and young people’s cancers
CONCLUSIONS: In order to improve public and patient trust in our use of data for research, we need to improve communication about how data is used and the benefits that arise. Res Involv Engagem. 2023 Aug 29;9(1):71. doi: 10.1186/s40900-023-00485-8. ABSTRACT BACKGROUND: In the United Kingdom, healthcare data is collected on all patients receiving National Health […]
Regional perspectives on the coordination and delivery of paediatric end-of-life care in the UK: a qualitative study
CONCLUSIONS: Findings demonstrate how informal and formal relationships between organisations and individuals, enabled early communication with families, and collaborative working with specialist services. Formalising these could increase knowledge and awareness of end of life care, improve staff confidence, and overall improve professionals’ experiences of delivering care, and families’ experiences of receiving it. There are considerable […]